SEN 1269

Research use only, not for human use.

SEN1269 is a novel potent Aβ aggregation inhibitor that binds to monomeric Aβ1-42 with Kd of 4.4 uM.

SEN1269 is a novel potent Aβ aggregation inhibitor that binds to monomeric Aβ1-42 with Kd of 4.4 uM, protects neuronal cell lines against an Aβ1-42 insult with IC50 of 15 uM; produces a concentration-related blockade of Aβ(1-42) aggregation and protects neuronal cell lines exposed to Aβ(1-42); alleviates deficits in hippocampal LTP induced by Aβ(1-42) and cell-derived Aβ oligomers; reduces Aβ-induced neurotoxicity and shows neuroprotective in behavioural models of memory relevant to Aβ-induced neurodegeneration.

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SEN1269

Others

Amyloids

Amyloids

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956128-01-1

322.368

C18H18N4O2

>98% (HPLC)

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OC1=CC=CC(NC2=NC=C(OC3=CC=CC(N(C)C)=C3)C=N2)=C1

3-((5-(3-(dimethylamino)phenoxy)pyrimidin-2-yl)amino)phenol

(-20℃)

With Ice Pack

≥ 2 years